Asteroid Isis is chiefly worshiped as the Goddess of motherhood, magic and fertility. She is also the protector of dead and devoted wife. Isis famously scoured the earth for the dismembered parts of her husband Osiris’s body after his jealous brother Set had chopped him into 14 pieces. She recovered 13 parts, but needed to use her magical ability to create the missing phallus, breathe new life into and even have a son from her formerly dead husband.
Isis’s theme is bringing together, unifying and guarding the Pharaoh; she is the seat of power, the throne and her husband’s support. Isis is also about resurrection, re-assembling and re-membering. Isis is the Egyptian equivalent of Virgo and is the uber-goddess, originator of all dark lunar goddesses. She is the daughter of Nut, the night sky, the nothingness that strings together and upholds the stars with invisible support. Just like her mother she stitches together parts to create one whole being. She creates and unifies.
Asteroid Isis Horoscope
Isis was discovered in 1856 in Oxford. The time is an estimate, so I won’t look at the angles. She has Sun sextile Jupiter, Sun trine Lilith and Sun trine Mars which together befit the Goddesses of all Goddesses as a regal warrior queen.Mars opposite Jupiter gives her invincibility and passion to pursue a difficult mission against all odds, to the bitter end. The Sun aspecting two sides of the opposition harmoniously, ensures diplomacy and success. Representing the Virgo archetype, Isis has Spica on the South Node “It gives success, renown, riches, a sweet disposition, love of art and science, unscrupulousness, unfruitfulness and injustice to innocence.”  Ceres (Spica) itself is on Rigel, which happens to be in her husband Osiris’s constellation Orion. “It gives benevolence, honor, riches, happiness, glory, renown and inventive or mechanical ability.”
Mercury is on Betelgeuse also in Orion! Here it brings “Serious, studious, scientific and literary, fame through writings.” Isis’s strong connection to magic is found in the gift of the Moon/Neptune/Uranus minor grand trine. It’s just wonderful to have the mystic Neptune working in harmony with intuitive flashes from Uranus, both plugging into her lunar wisdom. Moon on Peacock gives her charisma and flamboyant charm.“Pavo is said to give vanity and love of display, together with a long life and sometimes fame.” 
Asteroid Isis in Astrology
I would expect then to see Isis strong in writers and strategists. People who can collate disperate information and breathe new life into it. Mars quincunx Pluto is passion and the killer instinct, but the Venus sextile Neptune shows her softer side and utter devotion in love. Those who have a career in the occult and astrology would find Isis very useful to have in their charts because of the strong Mercury and the ability to divine a coherent message from many different symbols. Isis probably carries with it some chance of fame judging by the amount of stars she has promising renown. Hilary Clinton is a good example of a regal Isis woman standing by her man, success in writings and certainly fame. She has Isis in a stellium conjunct Venus and Chiron.
1, 2,3 & 4. Fixed Stars and Constellations in Astrology, Vivian E. Robson, 1923. p.211, p.197-198, p.147, p.55.
Find Asteroid Isis in Your Chart
1. Create your chart HERE.
2. Choose “Extended Chart Selection”.
3. In “additional asteroids or hypothetical planets” add 42.